Flagship Product · Ketoprofen Chain

Methyl 3-(Cyanomethyl)benzoate

Start two steps earlier and run green DMC methylation in-house. For full-route plants, NCB is the cost-optimized entry point into the Ketoprofen chain — with finished CEBA available whenever you prefer to skip upstream.

CAS 68432-92-8 C₁₀H₉NO₂ MW 175.18 Purity ≥ 99.0% (HPLC)

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Route Position

Where NCB Fits in the Ketoprofen Chain

For plants running the full route: NCB → CEBA via green DMC methylation. The downstream core intermediate CEBA is also available directly.

This Product

NCB
Methyl 3-(cyanomethyl)benzoate

CAS 68432-92-8

WE SUPPLY

Green methylation
DMC / K₂CO₃

➜

Downstream

CEBA
3-(1-Cyanoethyl)benzoic acid

CAS 5537-71-3
view product →

SOCl₂
acyl chloride

➜

Your Plant

Friedel–Crafts
(benzene / AlCl₃)

intermediate step

H₂SO₄ hydrolysis
120–140 °C

➜

API

Ketoprofen

99% step yield · 99.5%+ purity (lit.)

Technical Data

Product Specifications

Identity data verified against PubChem (CID 10821136). Batch-specific COA with every shipment.

No.	Test Parameter	Specification
Appearance	Colourless to light-yellow liquid
Purity (GC/HPLC)	≥ 95.0%
Boiling Point	314.1 ± 25.0 °C
Density	1.141 ± 0.06 g/cm³

Sourcing Decision

Start from NCB or Buy CEBA Direct?

Two entry points on the same chain — pick by your workshop capability, not by guesswork.

🛠 Buy NCB — run 2 steps in-house

For plants with methylation + hydrolysis capacity: DMC / K₂CO₃ (~180 °C, 3 MPa, 30 h) → hydrolysis to CEBA. Lower front-end cost, full route control, iodine-free green chemistry.
Source: CN105037127A

Buy CEBA — skip to step 4

For buyers who only run the back end: acyl chloride → Friedel–Crafts → hydrolysis, three steps to API. Less equipment, faster batches.
See CEBA product page →

⚠ NCB and CEBA are constitutional isomers (C₁₀H₉NO₂ — ester vs acid). Always distinguish by CAS in POs and warehouse intake: NCB 68432-92-8 · CEBA 5537-71-3.

Export Ready

Packing & Logistics

Custom packing and documentation for pharma-intermediate supply chains. Full traceability per batch.

Physical form: Colourless to light-yellow liquid (CEBA is a carboxylic-acid solid)
Packing: 200 kg plastic drum; custom subdivision on request
Documentation: COA, TDS, SDS per batch; DMF-support data on request
Storage: Sealed, dry, room temperature or cool ventilated; protect from humidity and light
Port of Loading: Ningbo / Shanghai, China
Lead Time: 15–25 days after order confirmation
Supply Scale: Pilot to commercial quantities

Documentation

Downloads

Full technical data sheet for procurement records. Batch-specific COA issued with every shipment.

TDS & SDS — NCB (EN) Doc No. TDS&SDS-NCB-20260907-EN · PDF — request via inquiry Certificate of Analysis (COA) Issued per batch — request via inquiry

Get In Touch

Request a Quote or Sample

We respond within one business day. TDS, batch COA and route consultation available on request.

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