Ningbo Taikang Chemical

Route Position

Where CEBA Fits in the Ketoprofen Chain

Start from CEBA and your plant only runs the back end: acyl chloride → Friedel–Crafts → hydrolysis. Upstream precursor NCB also available.

Upstream

NCB
Methyl 3-(cyanomethyl)benzoate

CAS 68432-92-8
view product →

Green methylation
DMC / K₂CO₃

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This Product

CEBA
3-(1-Cyanoethyl)benzoic acid

CAS 5537-71-3

WE SUPPLY

SOCl₂
acyl chloride

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Your Plant

Friedel–Crafts
(benzene / AlCl₃)

intermediate step

H₂SO₄ hydrolysis
120–140 °C

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API

Ketoprofen

99% step yield · 99.5%+ purity (lit.)

Technical Data

Product Specifications

Identity data verified against PubChem (CID 98370). Batch-specific COA with every shipment.

No.	Test Parameter	Specification
Appearance	White to off-white crystalline powder
Melting Point	143–148 °C
Purity (HPLC)	≥ 99.0%
Total Impurities	≤ 1.0% (individual ≤ 0.1%, RRT 1.5 ≤ 0.15%)
Loss on Drying	≤ 0.5%
Sodium Chloride	≤ 1.0%

Downstream Markets

Three Outlets from One Intermediate

Every downstream figure is anchored to published patents — no marketing inflation.

💊 Ketoprofen API

NSAID (anti-inflammatory / analgesic / antipyretic) — tablets, injections, topical gels. From CEBA: acyl chloride → Friedel–Crafts → H₂SO₄ hydrolysis (130 °C / 8 h).
Step yield 99% · API purity 99.5–99.7% · overall route >90%.

Source: CN105037127A

Ketoprofen Ethyl Ester (Prodrug)

Propionitrile intermediate + ethanol / H₂SO₄, <60 °C dosing, reflux 5–18 h — prodrug for improved topical & transdermal delivery.
Yield 86–89.2%.

Source: CN102911057A

⚗️ S-(+)-Ketoprofen (Chiral)

High-value enantiomer via enzymatic resolution of the nitrile / amide — ee 93–100% with Brevibacterium / Corynebacterium strains; tablet / injection / gel formulations disclosed.

Source: US5,089,405

Export Ready

Packing & Logistics

Custom packing and documentation for pharma-intermediate supply chains. Full traceability per batch.

Standard Packing: 25 kg fiber drum (custom sizes on request)
Documentation: COA, TDS, SDS per batch; DMF-support data on request
Storage: Cool, dry, well-ventilated area; keep sealed, away from strong bases / oxidizers
Port of Loading: Ningbo / Shanghai, China
Lead Time: 15–25 days after order confirmation
Supply Scale: Pilot to commercial quantities

Documentation

Downloads

Full technical data sheet for procurement records. Batch-specific COA issued with every shipment.

TDS & SDS — CEBA (EN) Doc No. TDS&SDS-CEBA-20260907-EN · PDF — request via inquiry Certificate of Analysis (COA) Issued per batch — request via inquiry

Get In Touch

Request a Quote or Sample

We respond within one business day. TDS, batch COA and route consultation available on request.

📧 export@taikangchem.com WhatsApp

3-(1-Cyanoethyl)benzoic Acid